From New York Metropolitan area:
Take the Tappan Zee Bridge (Thruway North) to Exit 16; Route 17 west to Exit 84 for Deposit.  At Deposit, take Route 8 north to New Berlin, then Route 80 west to Sherburne and Route 12 north.  In Sherburne bear left at Route 12B to Hamilton.

From Boston:
Take Mass. Turn Pike west to NYS Thruway to Exit 25A for I-88 (Duanesburg), then I-88 west to Exit 24 for Route 20 west; beyond Madison turn left onto 12B south to Hamilton.

Or continue on NYS Thruway west to Exit 31 (Utica); follow the Arterial (Routes 5, 8, 12) south to Route 12B south to Hamilton.

From the West (Buffalo, Ohio, etc.):
Take the NYS Thruway east to Exit 33 (Verona); Route 365 south to Route 5 west in Oneida; south on Route 46 to Route 12B south to Hamilton.